Chr. Hansen Holding A/S, a leading global bioscience company, and Lonza AG, a leading pharma contract manufacturing company, have signed an agreement to establish a 50/50 joint venture to pioneer the live biotherapeutic products (LBP) industry and position themselves as the leading contract development and manufacturing partner (CDMO)for biotech and pharma customers. The joint venture will be a 50/50 controlled legal entity which will operate from its headquarters in Basel, Switzerland and have production facilities in Denmark and Switzerland.
The joint venture brings together best-in-class, complementary capabilities and will be the first CDMO globally to provide a full supply chain offering manufacturing of bacteria strains for therapeutic use. Whilst Chr. Hansen contributes its extensive know-how in developing, upscaling and manufacturing bacteria strains, Lonza brings strong capabilities in pharma contract manufacturing and outstanding formulation and drug delivery technologies. Furthermore, the joint venture will possess leading competences in handling, characterizing, formulating, manufacturing and encapsulating strict anaerobe bacteria. These competences under one roof, with seamless exchanges between drug substance and drug product activities will decrease development timelines and increase chance of ‘right-first-time’.
Says Mauricio Graber, CEO of Chr. Hansen: “The joint venture is a quantum leap for Chr. Hansen’s human microbiome lighthouse. It’s a great opportunity to utilize our microbial capabilities in the highly attractive LBP industry whilst sticking to our strategy of not becoming a fully-fledged pharma company. Chr. Hansen has more than 145 years of experience in strain development and manufacturing and we are thrilled to join forces with a leading global company in the
pharma CDMO market to become the partner of choice for end-to-end biotherapeutic solutions. The clinical trial supply industry is a rapidly emerging field, not to speak of the very large potential when the first bacteria-based medical products enter the commercial market,”
Said Mark Funk, CEO, Lonza Group: "We need to think differently about how we develop solutions for manufacturing in the microbiome space as we see the potential of this therapeutic area develop. By teaming up with Chr. Hansen, one of the world’s largest producers of bacteria, we are combining expertise that perfectly fits the very specific needs of aspirational companies in the microbiome space. Our customers will be able to draw on the unrivalled skillset of two world experts that master the exacting processes required for production of strict anaerobic microbes through to formulation and dosage forms. We understand the complexities of bringing pharmaceuticals to market, including the evolving regulatory environment, and will offer unique development and pharma-grade manufacturing that addresses an unmet need in the industry, enabling customers to deliver therapies for patients,”
The joint venture targets the emerging preclinical and clinical supply industry for LBP with a large upside to serve the ensuing commercial demand, once the first live biotherapeutic products will be approved and available for treatment. Given the current number of ongoing preclinical to phase III drug trials, the clinical supply industry globally is estimated to reach EUR 150-200 million by 2025. By 2035, the combined clinical and commercial supply industry is estimated to exceed EUR 1 billion. For more visit chr-hansen.com
Source: Chr HansenAuthor: COX