38
QUALITY MANAGEMENT
while Lycopsamine, Echinatin and their related N-oxides
were present in 3 samples.
Conclusion
A high sensitivity SFC-MS/MS method for analysis of 34 PAs
in plant material has been developed which achieves baseline
separation of 5 Lycopsamin and 2 Senecionin stereoisomers in
8 minutes. Applicability to food samples could be established
by determination of PA content in commercial tea samples.
The SFC-MS detected a number of PAs at lower levels than an
optimized UHPLC-MS assay, due to increased MS sensitivity.
References
1 BfR Opinion 018/2013: Pyrrolizidine alkaloids in herbal
teas and teas https://mobil.bfr.bund.de/cm/349/
pyrrolizidine-alkaloids-in-herbal-teas-and-teas.pdf
2 EFSA Journal 2017; 15(7): 4908: Risks for human
health related to the presence of pyrrolizidine
alkaloids in honey, tea, herbal infusions and food
supplements
3 S. Schramm, N. Köhler, W. Rozhon, Pyrrolizidine
Alkaloids: Biosynthesis, Biological Activities and
Occurrence in Crop Plants, Molecules 2019, 24,
498; doi: 10.3390 / molecules 24030498
Table 2: LLOQs for the different PAs
4 Method description BfR-PA-Tee-2.0/2014; Determination
of pyrrolizidine alkaloids (PA) in plant
material using SPE-LC-MS/MS
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